Fildena 120 mg contains sildenafil citrate, a medication used to treat erectile dysfunction (ED) in men. The mechanism of action of Fildena 120 mg is related to its active ingredient, which is a phosphodiesterase type 5 (PDE5) inhibitor. Here's how it works:

Phosphodiesterase Type 5 (PDE5) Inhibition: When a man is sexually aroused, the body releases nitric oxide (NO) in the penile tissue. Nitric oxide activates an enzyme called guanylate cyclase, which increases levels of cyclic guanosine monophosphate (cGMP). cGMP is a signaling molecule that relaxes the smooth muscle cells in the penile arteries, allowing blood to flow into the penis. This increased blood flow is necessary for an erection.

Breakdown of cGMP: In the absence of sexual arousal or after ejaculation, another enzyme called PDE5 breaks down cGMP, reducing its levels in the penile tissue. As cGMP decreases, the smooth muscles in the penile arteries contract, reducing blood flow, and the erection subsides.

Sildenafil's Role: Fildena 120 mg, with its active ingredient sildenafil citrate, works by inhibiting PDE5. By blocking the action of PDE5, sildenafil helps to maintain higher levels of cGMP in the penile tissue. This, in turn, allows the smooth muscles to remain relaxed, promoting increased blood flow to the penis.

Erection Facilitation: As a result of increased cGMP levels, the arteries in the penis dilate, and more blood flows into the erectile tissues. This improved blood flow leads to the development and maintenance of an erection when sexually aroused.