Malegra 120 is a medication that contains Sildenafil Citrate as its active ingredient. Sildenafil Citrate is a phosphodiesterase type 5 (PDE5) inhibitor, and it works by increasing blood flow to the penis during sexual stimulation. Here's a comprehensive guide on how Malegra 120 works:

Mechanism of Action: Malegra 120 primarily works by inhibiting the enzyme phosphodiesterase type 5 (PDE5). PDE5 is responsible for the breakdown of cyclic guanosine monophosphate (cGMP), a chemical messenger that plays a crucial role in relaxing the smooth muscles of the penis.

Nitric Oxide Release: When a man is sexually stimulated, the release of nitric oxide occurs in the erectile tissue of the penis. Nitric oxide activates the enzyme guanylate cyclase, leading to an increased production of cGMP.

Smooth Muscle Relaxation: Increased levels of cGMP cause the smooth muscles in the penile blood vessels to relax. This relaxation allows the blood vessels to dilate, facilitating an increased blood flow to the penis.

Increased Blood Flow: As the blood vessels widen and blood flow to the penile tissues is enhanced, the erectile tissue fills with blood, leading to an erection.

Erection Maintenance: Sildenafil Citrate helps to maintain the erection by preventing the premature breakdown of cGMP. By inhibiting PDE5, Sildenafil ensures that cGMP levels remain elevated, allowing for sustained blood flow to the penis during sexual activity.

It's important to note that Malegra 120 and other medications containing Sildenafil do not cause spontaneous erections. Sexual stimulation is necessary to initiate the release of nitric oxide and activate the cGMP pathway.